First, place less items on the screen. Only the most important content and features should be displayed. What’s normal for a 1024x768 + screen is overwhelming on a smaller screen resolution.
Second, use only one column. Eliminate what would otherwise be in the right column and place the navigation that might have been placed in the left column at the top and the bottom.
If you started designing websites in the 1990s this is a simple transition. For those who started designing after 1024 + screens became the norm … have fun. :-)